The end is near...
OK, I can answer this...but I'd first like to say that I really don't want to see 'genre-mashups'. Not when there are so few genres with a decent headline game.
If there a definitive Wild West game out there? A 60s Spy game? How about a Fantasy Folklore game, huh?
Yeah. Don't go putting your chocolate in my peanut butter until you can make really good chocolate.
That said...I wouldn't mind seeing a Medieval Fantasy/Mecha game that doesn't fall into the typical American default of making the mechs Steampunk contraptions, or regular Science Fiction robots. I want that mix of magical item, and fantasy engineering you see in Japanese TRPGs like Wares Blade, or Anime like Knights & Magic.
While I am not a big fan of traditional Fantasy settings, adding a giant robot makes anything better.